Anti-S-100 (beta-subunit) Monoclonal Antibody (Clone: SH-B1)

DESCRIPTION

S100 protein is a 21,000-Da component first isolated from brain by Moore(1965). Immunocytochemical studies demonstrated that S100 protein is produced by a wide variety of normal and neoplastic cells of mesodermal, neuroectodermal, and epithelial origin(Herrera et al., 1988). The S100 molecule is a dimer; thus there are 3 forms of S100: alpha-alpha, known as S-100a(0); alpha-beta, known as S-100a; and beta-beta, known as S-100b. S100 genes are clustered on human chromosome 1q21. S-100 protein expression by primary and metastatic adenocarcinomas.

DETAILS

Gene: S100b
App Id: IHC-P
Antigen: Protein S100-B
Gene Id: 25742
Isotype: Mouse IgG1
Clone Name: SH-B1
Uniprot Id: P04631
Host Animal: Mouse
Clonality Id: Monoclonal
Purification: Ascites
Reactivity Id: Human
Product Content: Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Alternative Name: Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B; S100b
Application Note: Immunohistochemistry(Paraffin-embedded Section) : 1-2µg/ml
Storage Condition: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Immunogen Information: Bovine brain S-100b.