4570371-5mg 4570371-1mg
JAK Inhibitor I
Biogems
DESCRIPTION
JAK Inhibitor I is a potent and reversible Janus protein tyrosine kinases (JAKs) inhibitor that functions through its interaction with the ATP binding site. It is reported to inhibit the IL-2 and IL-4 dependent proliferation of CTLL cells and to block the phosphorylation of STAT5.
DETAILS
- Purity: ≥98%
- Synonyms: Pyridone 6, CMP-6, CMP 6
- Cas Number: 457081-03-7
- References: Efe, J. A., Hilcove, S., Kim, J., Zhou, H., Ouyang, K., Wang, G., ... & Ding, S. (2011). Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nature cell biology, 13(3), 215. Kim, J., Efe, J. A., Zhu, S., Talantova, M., Yuan, X., Wang, S., ... & Ding, S. (2011). Direct reprogramming of mouse fibroblasts to neural progenitors. Proceedings of the National Academy of Sciences, 108(19), 7838-7843. Pedranzini, L., Dechow, T., Berishaj, M., Comenzo, R., Zhou, P., Azare, J., ... & Bromberg, J. (2006). Pyridone 6, a pan-Janus–activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. Cancer research, 66(19), 9714-9721.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one
- Molecular Weight: 309.3
- Molecular Formula: C18H16FN3O
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC(C)(C)C1=NC2=C(N1)C3=C(C=C(C=C3)F)C4=C2C=CNC4=O