IT2-H53W6-100ug IT2-H53W6-1mg
Human Integrin alpha D beta 2 (ITGAD&ITGB2) Heterodimer Protein, His Tag&Tag Free
ACROBiosystems
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DESCRIPTION
Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Alpha D beta 2, selectively binds ICAM-3 and does not appear to bind ICAM-1. In addition, a soluble form of alpha D beta 2 binds VCAM-1 with greater efficiency relative to ICAM-3. The I domain of alpha D contains a binding site for VCAM-1 since recombinant alpha D I domain binds specifically to VCAM-1.
DETAILS
- Tag: C-10×His | Native
- Host: CHO
- Size: 1mg
- Buffer: 50 mM Tris, 150 mM NaCl, pH7.5
- Format: Powder
- Purity: 90%
- Source: Human ITGAD&ITGB2 Heterodimer Protein, His Tag&Tag Free (IT2-H53W6) is expressed from CHO cells. It contains AA Phe 18 - Asn 1099 (ITGAD) & Gln 23 - Asn 700 (ITGB2) (Accession # Q13349-1 (ITGAD) & P05107-1 (ITGB2)).
- Storage: -20℃
- Category: Bio-Markers & CD Antigens
- Molecule: Integrin alpha D beta 2
- Accession: NP_005344.2 | NP_000202.3
- Conjugate: Unconjugated
- Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Exp Region: Phe 18 - Asn 1099 (ITGAD) & Gln 23 - Asn 700 (ITGB2)
- Swiss-prot: Q13349-1 (ITGAD) & P05107-1 (ITGB2)
- Package Size: 100ug*10
- Characteristics: Human Integrin alpha D beta 2 (ITGAD&ITGB2) Heterodimer Protein, produced by co-expression of ITGAD and ITGB2, has a calculated MW of 124.9 kDa (ITGAD) and 80.2 kDa (ITGB2). Subunit ITGAD is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The protein migrates as 150 kDa (ITGAD) and 90-100 kDa (ITGB2) under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level: 1.0 EU per μg
- Molecular Weight: 124.9 kDa | 80.2 kDa
- Shipping Condition: RT
- Species Reactivity: Human
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