GMA-H5145-20ug GMA-H5145-50ug GMA-H5145-500ug
Human GMF-beta Protein, His Tag (MALS verified)
ACROBiosystems
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DESCRIPTION
Glia Maturation Factor-Beta (GMF-Beta) is a 17 kDa protein nerve gorwth factor identified as a growth and differentiation factor in the vertebrate brain.
Glia Maturation Factor-Beta stimulates differentiation of normal neurons as well as glial cells. GMFB inhibits the proliferation of the N-18 neuroblastoma line and the C6 glioma line while promoting their phenotypic expression.
GMF-beta inhances the phenotypic expression of glia & neurons thus inhibits the proliferation of their respective tumors when added to cell culture. Although astrocytes produce GMF-b and stores it inside the cells, they don’t secrete the GMF-B into the cultured medium. Cell- surface GMFb acts on the target cells at close range when cells are in direct contact. GMF-Beta is produced by thymic epithelial cells and plays an important role in T cell development in favor of CD4+ T cells.
GMF-Beta is a brain-specific protein which belongs to the actin-binding proteins (ADF) family. GMF-beta appears to play a role in the differentiation, maintenance, and regeneration of the nervous system. It also supports the progression of certain auto-immune diseases, possibly through its ability to induce the production and secretion of various pro-inflammatory cytokines.
DETAILS
- Tag: N-10×His
- Host: E. coli
- Size: 500ug
- Buffer: PBS, pH7.4
- Format: Powder
- Purity: 95%
- Source: Human GMF-beta, His Tag (GMA-H5145) is expressed from E. coli cells. It contains AA Ser 2 - His 142 (Accession # P60983).
- Storage: -20℃
- Category: Other Recombinant Proteins
- Molecule: GMF-beta
- Conjugate: Unconjugated
- Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Exp Region: Ser 2 - His 142
- Swiss-prot: P60983
- Package Size: 500ug*1
- Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.6 kDa. The protein migrates as 19-21 kDa under reducing (R) condition (SDS-PAGE).
- Endotoxin Level: 0.01 EU per μg
- Molecular Weight: 18.6 kDa
- Shipping Condition: RT
- Species Reactivity: Human
- Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html