mouse monoclonal IgG1; Wip1 Antibody (F-10) is an IgG1 κ mouse monoclonal Wip1 antibody (also designated PPM1D antibody, or WIP1 antibody) that detects the Wip1 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Wip1 Antibody (F-10) is available as both the non-conjugated anti-Wip1 antibody form, as well as multiple conjugated forms of anti-Wip1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Several major serine/threonine protein phosphatases have been identified in eukaryotic cells. These include protein phosphatase families 1, 2A, 2B, 2C, X and Y (PP-1, PP-2A, PP-2B, PP-2C, PP-X and PP-Y). These enzymes can be distinguished by their action on phosphorylase kinase and their sensitivity to certain activators and inhibitors. Wip1 (wildtype p53-induced phosphatase or PPM1D), a protein identified in the p53 DNA response pathway, is a member of the PP-2C family. Wip1 is a serine/threonine protein phosphatase which selectively inactivates p38 MAPK and dephosphorylates the ATM/ATR targets, Chk1 and p53. Wip1 is ubiquitously expressed but is present at very high levels in testis. Deletion of Wip1 results in a reduction of T and B cell function and compromised cell division, rendering cells resistant to becoming cancerous and slowing tumor development.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.