sc-74462 SAMPLE sc-74462
Promo Available
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Calbindin D9K (D-5)
Santa Cruz Biotechnology
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DESCRIPTION
mouse monoclonal IgG2a; Calbindin D9K Antibody (D-5) is an IgG2a κ mouse monoclonal Calbindin D9K antibody (also designated calbindin 3 antibody, calbindin-D9k antibody, enterocyte (intestinal epithelial cells) antibody, calbindin D9K antibody, cytosolic vitamin D-dependent calcium-binding protein antibody, or ATP-dependent Ca2+ transporter antibody) that detects the Calbindin D9K protein of human origin by WB, IP, IF, IHC(P) and ELISA. Calbindin D9K Antibody (D-5) is available as both the non-conjugated anti-Calbindin D9K antibody form, as well as multiple conjugated forms of anti-Calbindin D9K antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The family of EF-hand type Ca2+-binding proteins includes Calbindin D28K (previously designated vitamin D-dependent Ca2+-binding protein), Calbindin D9K, S-100 α and β, Calgranulin A (also designated MRP8), Calgranulin B (also designated MRP14) and Calgranulin C, and the Parvalbumin family members, including Parvalbumin α and Parvalbumin β (also designated oncomodulin). The gene encoding human Calbindin D9K is located on the X chromosome and consists of three exons and contains four Alu repeats. Calbindin D9K protein is present in cartilage, bone and certain teeth, such as the ameloblasts of incisors and molars. In addition, Calbindin D9K mRNA is detected in proximal small intestine, but not in human kidney, uterus or placenta (however, the protein is present in these tissues in other species). Rat Calbindin D9K binds the estrogen receptor because the gene encoding it contains an estrogen response element downstream from its promoter. In contrast, the homologous human sequence differs by two essential nucleotides and does not bind the estrogen receptor, suggesting that this change suppresses gene expression in human tissues, such as uterus and possibly placenta.
DETAILS
- Host: mouse
- Type: Primary
- Uniprot: P29377
- Clonality: Monoclonal
- Conjugate: unconjugated
- Applications: WB, IP, IF, IHC(P), ELISA
- Human Gene Id: 795
- Protein Target: Calbindin D9K
- Human Gene Name: S100G
- Species Reactivity: human
PROMOTION TERMS
Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.
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