Human IL-17 RA&IL-17 RC Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)

DESCRIPTION

Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation.

DETAILS

Tag: C-Fc | C-Fc
Host: HEK293
Size: 1mg
Buffer: PBS, pH7.4
Format: Powder
Purity: 95%
Source: Human IL17RA&IL17RC Protein, Fc Tag&Fc Tag (ILC-H5257) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Trp 320 (IL-17RA) & Leu 21 - His 465 (IL-17RC) (Accession # Q96F46-1 (IL-17RA) & NP_703190.1 (IL-17RC)).
Storage: -20℃
Category: Cytokines&Growth Factors
Molecule: IL-17 RA & IL-17 RC
Conjugate: Unconjugated
Stability: ●-20 to -70°C for 12 months in lyophilized state from date of receipt; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Leu 33 - Trp 320 (IL-17RA) & Leu 21 - His 465 (IL-17RC)
Swiss-prot: Q96F46-1 (IL-17RA) & NP_703190.1 (IL-17RC)
Package Size: 500ug*2
Characteristics: Human IL17RA & IL17RC Protein, Fc Tag&Fc Tag is produced by co-expression of IL-17RA and IL-17RC, has a calculated MW of 60.0 kDa (IL-17RA) & 75.7 kDa (IL-17RC). Subunit IL-17RA is fused with a human IgG1 Fc tag at the C-terminus and subunit IL-17RC is fused with a human IgG1 Fc tag at the C-terminus. The protein migrates as 80-90 kDa and 100-110 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to Glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 60.0 kDa (IL-17 RA) & 75.7 kDa (IL-17 RC)
Shipping Condition: RT
Species Reactivity: Human
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