GMP Human IFN-gamma Protein

DESCRIPTION

Interferon-gamma (IFN-γ/IFNG) is a dimerized soluble cytokine that is the only member of the type II class of interferon. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-γ belongs. IFN-gamma has been used in a wide variety of clinical indications. Interferon-gamma (IFNgamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression.

DETAILS

Tag: Native
Host: HEK293
Size: 50ug
Buffer: PBS, pH7.4
Format: Powder-GMP
Purity: 95%
Source: GMP Human IFN-gamma Protein (GMP-IFGH24) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Gln 166 (Accession # P01579).
Storage: -20℃
Category: Cytokines&Growth Factors
Molecule: IFN-gamma
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 5 years in lyophilized state; ● -70°C for 12 months under sterile conditions after reconstitution. Upon receipt, store it immediately at -20°C or lower for long term storage.
Exp Region: Gln 24 - Gln 166
Swiss-prot: P01579
Package Size: 50ug*1
Characteristics: This protein carries no "tag". The protein has a calculated MW of 16.8 kDa. The protein migrates as 15 kDa, 19 kDa and 24 kDa±3 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 10 EU/mg
Molecular Weight: 16.8 kDa
Shipping Condition: Blue ice
Species Reactivity: Human
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