Mouse LAIR1 / CD305 Protein, His Tag (MALS verified)

DESCRIPTION

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.

DETAILS

Tag: C-10×His
Host: HEK293
Size: 100ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 90%
Source: Mouse LAIR1 Protein, His Tag (LA1-M52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Tyr 141 (Accession # Q8BG84-1).
Storage: -20℃
Category: Immune Checkpoint Proteins
Molecule: LAIR-1
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Gln 22 - Tyr 141
Swiss-prot: Q8BG84-1
Package Size: 100ug*1
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.4 kDa. The protein migrates as 17-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 15.4 kDa
Shipping Condition: RT
Species Reactivity: Mouse
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