IL-1β, Rat

DESCRIPTION

Interleukin-1 Beta (IL-1 Beta) is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta bind to the same receptor and have similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine.

DETAILS

Form: Lyophilized
Purity: > 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
Species: Rat
Product Line: Cytokines
Expression System: E. coli
Storage Stability: Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
Biological Activity: ED50 < 10.0 pg/ml, measured by a cell proliferation assay using mouse D10S cells, corresponding to a specific activity of > 1.0 × 108 units/mg.
Protein Construction: IL-1β (Val117-Ser268)\nAccession # Q63264