EM0391
Anti-EpCAM (Extracellular region) Antibody
PhosphoSolutions
DETAILS
- Form: Protein G Purified
- Gene: EPCAM
- Host: Mouse
- Rrid: AB_3068418
- Type: Primary Antibody
- Clone: M039
- Buffer: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
- Target: EpCAM (Extracellular region)
- Isotype: IgG1
- Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
- Shipping: Blue Ice
- Synonyms: GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1, Epitelial glycoprotein, EGP, KS 1/4 antigen, KSA, EGP314, CD326, EpCAM
- Clonality: Mouse Monoclonal
- Immunogen: Clone (M039) was generated from the extracellular region of human EpCAM.
- Expiration: After date of receipt, stable for at least 1 year at -20°C.
- Specificity: Clone M039 mouse monoclonal antibody detects a 35-45 kDa* protein on SDS-PAGE "Native" immunoblots of human A431, H1915, and MCF7 carcinomas. This antibody weakly detects denatured EpCAM. The antibody works for native western blot, immunoprecipitation, ELISA capture, and immunocytochemistry.
- Applications: WB, ICC, IP
- Conjugate Exem: Unconjugated
- Physical State: Liquid
- Quality Control: Western blots performed on each lot.
- Usage Statement: For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
- Molecular Weight: 35-45
- Dilution Range Ip: 1:100
- Dilution Range Wb: 1:1000
- Immunogen Species: Human
- Dilution Range Icc: 1:100
- Species Reactivity: Human
- Target Description: Epithelial Cell Adhesion Molecule (EpCAM) is a signal type I transmembrane glycoprotein that has an extracellular domain with one thyroglobulin type-1 domain and a short cytoplasmic domain. EpCAM is found on the surface of adenocarcinoma, but not on mesodermal or neural cell membranes. The EpCAM molecule has been shown to function as a homophilic Ca2+ independent adhesion molecule. It may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium. Defects in EpCAM cause hereditary non-polyposis colorectal cancer type 8 (HNPCC8) and diarrhea type 5 (DIAR5). EpCAM plays a role in embryonic stem cell proliferation and differentiation; it up-regulates the expression of FABP5, MYC, and Cyclin A & Cyclin E. It is highly and selectively expressed by undifferentiated embryonic stem cells and in many types of epithelial carcinomas.
- Uniprot Number Immunogen Species: P16422
- Post Translational Modification Type: GOmAb
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