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33089

Carbazomycin B

Cayman Chemical

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DETAILS

  • Inchi: InChI=1S/C15H15NO2/c1-8-9(2)15(18-3)14(17)12-10-6-4-5-7-11(10)16-13(8)12/h4-7,16-17H,1-3H3
  • Purity: ≥95%
  • Raptas: Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Pesticides|Fungicides||Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Lipid Biochemistry|Lipoxygenase Pathways
  • Smiles: OC1=C2C3=CC=CC=C3NC2=C(C)C(C)=C1OC
  • Inchikey: OBMFXFPFPDTBHG-UHFFFAOYSA-N
  • Cas Number: 75139-38-7
  • Formulation: A solid
  • Item Origin: Bacterium/Streptomyces sp.
  • Storage Temp: -20
  • Shipping Temp: -20
  • Formula Markup: C15H15NO2
  • Formula Weight: 241.3
  • Shelf Life Days: 1460

DESCRIPTION

A bacterial metabolite with diverse biological activities; active against a panel of seven fungi (MICs = 3.2-200 µg/ml) and a panel of seven bacteria (MICs = 25-50 µg/ml), as well as P. falciparum and C. albicans (IC50s = 2.37 and 19.6 µg/ml, respectively); active against a panel of five plant-pathogenic fungi (MICs = 12.5-200 µg/ml); cytotoxic to MCF-7, KB, NCI H187, and Vero cells (IC50s = 8.4, 8.6, 4.2, and 48.9 µM, respectively); inhibits 5-LO activity in RBL-1 cell extracts (IC50 = 1.5 µM)