Cynomolgus Fc gamma RI / CD64 Protein, His Tag (MALS & SPR verified)

DESCRIPTION

Receptors that recognize the Fc portion of IgG are divided into three groups designated Fc gamma RI, RII, and RIII, also known respectively as CD64, CD32, and CD16. Fc gamma RI binds IgG with high affinity and functions during early immune responses. Fc gamma RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. High affinity immunoglobulin gamma Fc receptor I is also known as FCGR1A, FCG1, FCGR1, CD64 and IGFR1, is a type of integral membrane glycoprotein that binds monomeric IgG-type antibodies with high affinity, which belongs to the immunoglobulin superfamily or FCGR1 family. FCGR1A / CD64 contains 3 Ig-like C2-type (immunoglobulin-like) domains. CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells.

DETAILS

Tag: C-10×His
Host: HEK293
Size: 1mg
Buffer: PBS, pH7.4
Format: Powder
Purity: 95%
Source: Cynomolgus CD64, His Tag (FCA-C52H6) is expressed from human 293 cells (HEK293). It contains AA Val 11 - Pro 288 (Accession # NP_001270969.1).
Storage: -20℃
Category: MABSol® Fc Receptors
Molecule: Fc gamma RI / CD64
Accession: NP_001270969.1
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Val 11 - Pro 288
Package Size: 500ug*2
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 33.2 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 33.2 kDa
Shipping Condition: RT
Species Reactivity: Cynomolgus
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