Mouse KLRG1 Protein, His Tag (MALS & SPR verified)

DESCRIPTION

The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence. KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells. Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.

DETAILS

Tag: N-10×His
Host: HEK293
Size: 1mg
Buffer: PBS, pH7.4
Format: Powder
Purity: 95%
Source: Mouse KLRG1, His Tag (KL1-M5249) is expressed from human 293 cells (HEK293). It contains AA Gln 57 - Tyr 188 (Accession # O88713-1).
Storage: -20℃
Category: Other Recombinant Proteins
Molecule: KLRG1
Accession: NM_016970.1
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Gln 57 - Tyr 188
Swiss-prot: O88713-1
Package Size: 500ug*2
Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 17.1 kDa. The protein migrates as 24-27 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 17.1 kDa
Shipping Condition: RT
Species Reactivity: Mouse
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