Ganglioside GM3 (bovine brain) (sodium salt)

DESCRIPTION

A ganglioside GM3 with C18:1 and C20:1 sphingoid backbones; demonstrates antiproliferative and pro-apoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation; suppresses angiogenesis and reduces proliferation and migration of HUVECs at 20 μM; induces dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains

DETAILS

Inchi: InChI=1S/C59H108N2O21.Na/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-46(69)61-40(41(66)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)38-77-56-51(73)50(72)53(45(37-64)79-56)80-57-52(74)55(49(71)44(36-63)78-57)82-59(58(75)76)34-42(67)47(60-39(3)65)54(81
Purity: ≥98%
Raptas: Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cardiovascular System|Vasculature|Angiogenesis||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Lipid Biochemistry|Sphingolipids
Smiles: O[C@@H]1[C@@H]([C@H]([C@@H](O[C@@H]1CO)O[C@H]2[C@@H]([C@H]([C@@H](O[C@@H]2CO)OC[C@@]([H])([C@](O)(/C=C/CCCCCCCCCCCCC)[H])NC(CCCCCCCCCCCCCCCCC)=O)O)O)O)O[C@]3(O[C@H]([C@@H]([C@H](C3)O)NC(C)=O)[C@@]([H])([C@]([H])(O)CO)O)C([O-])=O.[Na+]
Inchikey: GGQRTSSCXQEZNW-BLVJLEROSA-M
Cas Number: 54827-14-4
Formulation: A lyophilized solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C59H107N2O21 • Na (for tricosanoyl)
Formula Weight: 1203.5
Shelf Life Days: 1460