GABRA1 Blocking Peptide (C-term)

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 2554
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: GABRA1
Other Names: Gamma-aminobutyric acid receptor subunit alpha-1, GABA(A) receptor subunit alpha-1, GABRA1
Availability: 2 weeks
Bio Background: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel (By similarity).
Bio References: Schofield P.R.,et al.FEBS Lett. 244:361-364(1989). Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. Garrett K.M.,et al.Biochem. Biophys. Res. Commun. 156:1039-1045(1988). Lachance-Touchette P.,et al.Eur. J. Neurosci. 34:237-249(2011). Carvill G.L.,et al.Neurology 82:1245-1253(2014).
Primary Accession: P14867
Targetspecificity: The synthetic peptide sequence is selected from aa 405-418 of HUMAN GABRA1