Gefitinib-based PROTAC 3

DESCRIPTION

A PROTAC comprised of gefitinib linked to VHL ligand 1; induces degradation of EGFR containing the activating mutation L858R or an exon 19 deletion (DC50s = 22.3 and 11.7 nM, respectively) but does not induce degradation of wild-type EGFR at ≤10 μM in cell-based assays

DETAILS

Inchi: InChI=1S/C47H57ClFN7O8S/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-33(57)26-56(38)46(60)43(47(2,3)4)55-41(58)15-18-63-20-19-62-16-7-6-8-17-64-40-23-34-37(24-39(40)61-5)51-27-52-44(34)54-32-13-14-36(49)35(48)21-32/h9-14,21,23-24,27-28,33,38,43,57H,6-8,15-20,22,25-26H2,1-5H3,(H,50,59)(H,55,58)(H,51,52,54)/t33-,38+,43-/m1/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|PROTACs||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System
Smiles: ClC1=CC(NC2=NC=NC3=C2C=C(OCCCCCOCCOCCC(N[C@@H](C(C)(C)C)C(N4C[C@H](O)C[C@H]4C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)C(OC)=C3)=CC=C1F
Inchikey: NICKHWYZMNLEPJ-TZSMONEZSA-N
Cas Number: 2230821-27-7
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C47H57ClFN7O8S
Formula Weight: 934.5
Shelf Life Days: 1460