ART3 Antibody (C-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 419
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: ART3
Other Names: Ecto-ADP-ribosyltransferase 3, ADP-ribosyltransferase C2 and C3 toxin-like 3, ARTC3, Mono(ADP-ribosyl)transferase 3, NAD(P)(+)--arginine ADP-ribosyltransferase 3, ART3, TMART
Availability: 2 weeks
Bio Background: Mono-ADP-ribosylation involves the transfer of the ADP-ribose moiety from NAD+ to a specific amino acid in the target protein. The rodent mono-ADP-ribosyltransferase RT6 is a glycosylphosphatidylinositol (GPI)-anchored membrane protein specifically expressed at the cell surface of rat and mouse T lymphocytes. The predicted 367-amino acid human ART3 protein has an estimated molecular mass of 41.5 kD and contains a hydrophobic peptide signal at its N terminus, 3 consensus motifs specific to enzymes catalyzing ADP-ribose transfer, a hydrophobic C-terminal sequence characteristic of a GPI-anchored protein, a novel motif repeated 3 times at its C terminus, and 1 potential glycosylation site.1 The ART3 and rodent RT6 proteins share 35% amino acid identity.
Bio References: Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Koch-Nolte, F., et al., Genomics 39(3):370-376 (1997).Levy, I., et al., FEBS Lett. 382(3):276-280 (1996).
Other Accession: NP_001170
Primary Accession: Q13508
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP2312b was selected from the C-term region of human ART3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.