12-9019
Anti-CD38 antibody(DM28), Rabbit mAb
Abeomics
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DESCRIPTION
CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.
DETAILS
- App Id: ELISA,FACS
- Isotype: Rabbit IgG
- Clone Name: DM28
- Host Animal: Rabbit
- Clonality Id: Monoclonal
- Purification: Purified from cell culture supernatant by affinity chromatography
- Reactivity Id: Human
- Alternative Name: T10, cADPr hydrolase 1
- Application Note: Recommended Dilutions ELISA 1/5000-10000; FACS 1/100
- Storage Condition: Store at -20°C for 12 months (Avoid repeated freezing and thawing)
- Shipping Condition: Delivery in 1-2 weeks
- Immunogen Information: Recombinant human CD38 (Val43-IIe300) produced by using human HEK293 cells