mouse monoclonal IgG2a; TRB-3 Antibody (B-2) is an IgG2a λ mouse monoclonal TRB-3 antibody that detects TRB-3 of mouse, rat and human origin by WB, IP, IF and ELISA. TRB-3 Antibody (B-2) is available as the non-conjugated anti-TRB-3 antibody form, as well as multiple conjugated forms of anti-TRB-3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. TRB-3 (tribbles 3), also called NIPK (neuronal cell death-inducible protein kinase) disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. TRB3 binds to ATF4, inhibiting its transcriptional activation activity, and regulates activation of MAP kinases. In the liver, TRB-3 is a target for PPAR-alpha. Amounts of TRB3 RNA and protein are higher in livers of diabetic mice compared with those in wildtype mice. TRB3 contributes to insulin resistance in individuals with susceptibility to type II diabetes. Highest expression of TRB-3 is in liver, pancreas, peripheral blood leukocytes and bone marrow.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.