V-9302

DESCRIPTION

An inhibitor of ASCT2; inhibits glutamine uptake (IC50s = 9 and 9.6 µM for the rat and human transporters, respectively); reduces cell viability of a variety of cancer cell lines, including HCT116, HT-29, COLO 205, and RKO cells (EC50s = 8.9, 9.4, 14.5, and 8.3 µM, respectively); reduces glutamine uptake into tumor tissue and prevents tumor growth in HCT116 and HT-29 mouse xenograft models expressing K-RasG13D and BRAFV600E mutations, respectively, at 75 mg/kg per day for 21 days

DETAILS

Inchi: InChI=1S/C34H38N2O4/c1-25-9-7-11-27(19-25)23-39-32-15-5-3-13-29(32)21-36(18-17-31(35)34(37)38)22-30-14-4-6-16-33(30)40-24-28-12-8-10-26(2)20-28/h3-16,19-20,31H,17-18,21-24,35H2,1-2H3,(H,37,38)/t31-/m0/s1
Purity: ≥95%
Raptas: Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Tumor Microenvironment
Smiles: CC1=CC=CC(COC2=C(CN(CC3=C(OCC4=CC(C)=CC=C4)C=CC=C3)CC[C@H](N)C(O)=O)C=CC=C2)=C1
Inchikey: YGKNVAAMULVFNN-HKBQPEDESA-N
Cas Number: 1855871-76-9
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C34H38N2O4
Formula Weight: 538.7
Shelf Life Days: 1460