mouse monoclonal IgG1; MATH-1 Antibody (18A6) is an IgG1 κ mouse monoclonal MATH-1 antibody (also designated MATH-1 antibody) that detects the MATH-1 protein of mouse, rat and human origin by WB and IP. MATH-1 Antibody (18A6) is available as both the non-conjugated anti-MATH-1 antibody form, as well as multiple conjugated forms of anti-MATH-1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Drosophila atonal gene produces a protein with basic helix loop helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system. Mammalian atonal homolog 1 (MATH-1) is a helix-loop-helix (HLH) transcription factor that is structurally homologous to the product of the Drosophila proneural gene atonal. MATH-1, so known as Atoh1, Ath1 or HATH-1, is a 351 amino acid protein with an atonal-related basic HLH domain. In mice, expression of MATH-1 takes place by embryonic day 9.5 and initially localizes to the cranial ganglions and the dorsal part of the central nervous system. Prominent expression of MATH-1 is in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by day 18 and is undetectable in the adult nervous system. It is suggested that MATH-1 may play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.