DESCRIPTION

• Purity: ≥98%
• Synonyms: Semaxinib, SU-5416, SU 5416
• Cas Number: 204005-46-9
• References: Fong, T. A. T., Shawver, L. K., Sun, L., Tang, C., App, H., Powell, T. J., ... & Ullrich, A. (1999). SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer research, 59(1), 99-106. Mendel, D. B., Laird, A. D., Smolich, B. D., Blake, R. A., Liang, C., Hannah, A. L., ... & Cherrington, J. M. (2000). Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent. Anti-cancer drug design, 15(1), 29-41. Smolich, B. D., Yuen, H. A., West, K. A., Giles, F. J., Albitar, M., & Cherrington, J. M. (2001). The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts. Blood, 97(5), 1413-1421.
• Application: FA
• Formulation: Crystalline solid
• Chemical Name: (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
• Molecular Weight: 238.3
• Molecular Formula: C15H14N2O
• Storage Conditions: Product should be kept at -20°C.
• Pubchem Openeye Can Smiles: CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C