RP01399
Recombinant Human TNFRSF18/CD357 Protein
ABclonal
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DESCRIPTION
GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.
DETAILS
- Tag: C-hFc&His
- Source: HEK293 cells
- Gene Id: 8784
- Species: Human
- Lead Time: 3-5 weekdays
- Swiss Prot: Q9Y5U5-1
- Research Areas: Immune Checkpoint,Bio-Markers & CD Antigens,TNF family
- Alternative Names: TNFRSF18,AITR,CD357,GITR,GITR-D
Equivalent Items
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