E0715Hu
Human Azurocidin, AZU ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.
DETAILS
- GeneID: 566
- Species: Human
- Storage: 2-8ºC
- MASS(Da): 26,886
- Synonyms: AZU 1;AZU1;Azurocidin;Cationic antimicrobial protein CAP37;HBP;Heparin-binding protein;hHBP
- Assay Time: 1h 30m
- Assay Type: Sandwich
- Gene Names: AZU1
- Reactivity: Human
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 0.05ng/ml
- Target Protein: AZU1
- Detection Range: 0.1-40ng/ml
- Full Product Name: Azurocidin
- Standard Solution: 48ng/ml
- UniProt Accession: P20160