Bi-Phospho-ALK(Y1282/1283) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 238
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: ALK
Other Names: ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD246, ALK
Availability: 2 weeks
Bio Background: The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
Bio References: Ardini, E., et al. Cancer Lett. 299(2):81-94(2010) Ohira, M., et al. Cancer Sci. 101(11):2295-2301(2010) Merkel, O., et al. Proc. Natl. Acad. Sci. U.S.A. 107(37):16228-16233(2010) De Brouwer, S., et al. Clin. Cancer Res. 16(17):4353-4362(2010) Bossi, R.T., et al. Biochemistry 49(32):6813-6825(2010)
Other Accession: P97793
Primary Accession: Q9UM73
Targetspecificity: The synthetic peptide sequence is selected from aa 1274-1287 of HUMAN ALK