mouse monoclonal IgG1; FBP3 Antibody (E-8) is an IgG1 κ mouse monoclonal FBP3 antibody (also designated FBP3 antibody) that detects the FBP3 protein of mouse, rat and human origin by WB, IP, IF and ELISA. FBP3 Antibody (E-8) is available as both the non-conjugated anti-FBP3 antibody form, as well as multiple conjugated forms of anti-FBP3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Activation of FUSE, the far-upstream element, is required for the proper ex-pression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP (FUSE-binding protein or Far upstream element binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL60 cells, FBP, FBP2, and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxyl-terminal activation domains. Expression of FBP is detected in undifferentiated cells and is substantially decreased following cellular differentiation.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.