Phospho-SAPK/JNK (Thr183/Tyr185) (Clone: A11) rabbit mAb FITC conjugate

DESCRIPTION

The SAPK/JNK pathway initiates apoptosis upon exposure to radiation, UV exposure, heat shock, oxidative stress, and other stressors. Upon exposure to environmental stress, the SAPK/JNK signaling pathway sequentially activates the proteins MEKK1, SEK1, SAPK, and c-Jun. Upstream activators of the SAPK/JNK cascade include ceramide, small GTP-binding proteins such as Rac1 and Cdc42Hs, Ask1, and caspases. MKK7 is also a major and direct SAPK/JNK activator in the TNF alpha or environmental stress signaling pathways, where its kinase activity directly phosphorylates SAPK/JNK. This relationship between MKK7 and SAPK appears to be evolutionarily conserved, as it is preserved in their Drosophila homologues, Hep and DJNK, respectively.

DETAILS

App Id: FACS
Isotype: Rabbit IgG1k
Format Id: Conjugated
Clone Name: SAPKT183Y185-A11
Host Animal: Rabbit
Clonality Id: Monoclonal
Conjugate Id: FITC
Reactivity Id: Human
Product Content: 1X PBS, 0.09% NaN3, 0.2% BSA
Alternative Name: Mitogen-activated protein kinase 8, MAPK8, Stress-activated protein kinase 1c, SAPK1c, c-Jun N-terminal kinase 1, JNK1, PRKM8
Application Note: For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.
Storage Condition: Store at 2-8°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: A synthetic phospho-peptide corresponding to residues surrounding Thr183/Tyr185 of human phospho SAPK/JNK