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Animal-Free Recombinant Human IL-1RA



Interleukin-1 receptor antagonist (IL-1RA) is a naturally-occurring, inflammatory-inhibitor protein. It inhibits the activity of IL-1alpha and IL-1beta by competitively blocking their binding to type I and type II receptors. IL-1RA is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Recombinant Human IL-1RA is a 17.2 kDa protein consisting of 153 amino acid residues.


  • Gene Id: 3554
  • Uniprot: P18510
  • Activity: Determined by its ability to inhibit the IL-1alpha stimulation of murine D10S cell. The expected ED50 is 20-40 ng/ml in the presence of 50 pg/ml of IL-1alpha.
  • Category: RUO Cytokines
  • Subcategory: Animal-Free Cytokines
  • Research Areas: Diabetes/Weight Regulation, Immune System, Inflammation, Neurobiology, COVID-19
  • Alternative Names: IL-1Ra, ICIL-1RA, IRAP, IL-1RN
  • Species of Origin: Human
  • Expression System Source: E.coli