E1572Hu
Human T-lymphocyte Activation Antigen Cd86, CD86 ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed: 7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). [Isoform 2]: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B.
DETAILS
- GeneID: 942
- Species: Human
- Storage: 2-8ºC
- MASS(Da): 37,682
- Synonyms: Activation B7-2 antigen;B70;BU63;CD 86;CD antigen CD86;CD86;CTLA-4 counter-receptor B7.2;FUN-1;T-lymphocyte activation antigen CD86;
- Assay Time: 1h 30m
- Assay Type: Sandwich
- Gene Names: CD86
- Reactivity: Human
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 0.05ng/ml
- Target Protein: CD86
- Detection Range: 0.1-40.ng/ml
- Full Product Name: T-Lymphocyte Activation Antigen CD86
- Standard Solution: 48ng/ml
- UniProt Accession: P42081