mouse monoclonal IgG2a; ORP-8 Antibody (PL-C26) is an IgG2a κ mouse monoclonal ORP-8 antibody (also designated ORP-8 antibody) that detects the ORP-8 protein of human origin by WB, IP and ELISA. ORP-8 Antibody (PL-C26) is available as the non-conjugated anti-ORP-8 antibody. Members of the oxysterol-binding protein (OSBP) family function as intracellular lipid receptors. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. ORPs (OSBP-related proteins) belong to a subfamily of OSBPs consisting of ORP-1 through ORP-11. The ORPs have a highly conserved OSBP-type sterol-binding region and a pleckstrin homology domain. They strongly bind to phosphatidic acid and weakly bind to phosphatidylinositol 3-phosphate. ORP-8 (oxysterol binding protein-like 8), also known as MST120, OSBP10, MSTP120 or OSBPL8, is an 889 amino acid widely expressed protein belonging to the OSBP family. Localized to the endoplasmic reticulum, ORP-8 suppresses ABC1 (ATP binding cassette transporter A1) expression and cholesterol efflux from macrophages. Existing as two isoforms due to alternative splicing events, ORP8 may modulate the development of atherosclerosis.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.