MS 245 (oxalate)

DESCRIPTION

An antagonist of 5-HT6 (Ki = 2.3 nM for the human recombinant receptor); selective for 5-HT6 over 5-HT2A and 5-HT2C receptors (Kis = 130 and 23 nM, respectively), as well as 5-HT1A, 5-HT1B, 5-HT1E, 5-HT3, and 5-HT7 receptors (Kis = 720, 9,200, 4,220, 2,390, and 600 nM, respectively); decreases cAMP production induced by 5-HT in HEK293 cells expressing 5-HT6 (pA2 = 8.88 nM); potentiates drug discrimination induced by (+)-amphetamine, but has no effect on cocaine or (–)-nicotine (Item No. 20887) drug discrimination in rats at 5 mg/kg

DETAILS

Inchi: InChI=1S/C19H22N2O3S.C2H2O4/c1-20(2)12-11-15-14-21(19-10-9-16(24-3)13-18(15)19)25(22,23)17-7-5-4-6-8-17;3-1(4)2(5)6/h4-10,13-14H,11-12H2,1-3H3;(H,3,4)(H,5,6)
Purity: ≥98%
Raptas: Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research
Smiles: COC1=CC=C(N(S(C2=CC=CC=C2)(=O)=O)C=C3CCN(C)C)C3=C1.OC(C(O)=O)=O
Inchikey: BLSWAEGCRSFTJG-UHFFFAOYSA-N
Cas Number: 275363-58-1
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C19H22N2O3S • C2H2O4
Formula Weight: 448.5
Shelf Life Days: 1460