mouse monoclonal IgG2a; PSMD4 Antibody (F-6) is an IgG2a κ mouse monoclonal PSMD4 antibody (also designated PSMD4 antibody) that detects the PSMD4 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. PSMD4 Antibody (F-6) is available as both the non-conjugated anti-PSMD4 antibody form, as well as multiple conjugated forms of anti-PSMD4 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. In eukaryotic cells, selective breakdown of cellular proteins is ensured by two distinct pathways. First, appropriate proteins are tagged for degradation by ubiquitination. Second, these multiubiquitinated proteins are degraded by the highly selective 26S proteasome protein-destroying machinery. At specific stages of development, embryo- and tissue-specific components of the 26S proteasome are formed, which are termed Rpn10a through Rpn10e. All members of this family can be generated by a single PSMD4 gene by developmentally regulated alternative splicing. PSMD4, originally identified as S5a (also designated antisecretory factor and multiubiquitin chain binding protein) is ubiquitously expressed and may perform proteolysis constitutively in a wide variety of cells. Rpn10D and Rpn10E may have embryo- or tissue-specific expression and may play specialized roles in early embryonic development.