mouse monoclonal IgG1; Sp3 Antibody (G-7) is an IgG1 κ mouse monoclonal Sp3 antibody (also designated Sp3 antibody or Transcription Factor SP3 antibody) that detects Sp3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Sp3 Antibody (G-7) is available as the non-conjugated anti-Sp3 antibody form, as well as multiple conjugated forms of anti-Sp3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Sp transcription factor family includes Sp1, Sp2, Sp3 (SPR-2) and Sp4 (SPR-1). Sp transcription factors share similar structures but do not share simi-lar functions. All four proteins contain a highly conserved DNA-binding domain composed of three zinc fingers at the C-terminus. Sp family members bind the consensus sequence GGGGCGGGGC and other closely related sequences which are known as GC boxes. Sp1, Sp3 and Sp4 share a high affinity for GC boxes while Sp2 does not. Sp2 only weakly binds to GT boxes. Sp1, Sp2 and Sp3 are ubiquitously expressed, while Sp4 is abundantly expressed in brain with limited expression in other tissues. Sp1 and Sp3, but not Sp2 or Sp4, interact with E2, a regulatory element for the β4 subunit of neuronal nicotinic acetylcholine receptors. Sp3 is the only Sp member to inhibit Sp1 and Sp4 mediated transcription. Multiple isoforms of Sp3 exist due to alternative splicing events.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.