Anti-Annexin A1 / (Hairy Cell Leukemia Marker) Monoclonal Antibody(Clone: CPTC-ANXA1-1)

DESCRIPTION:

The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, sµggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.

DETAILS

Gene: ANXA1
App Id: IP,WB,IHC
Gene Id: 301
Isotype: Mouse IgG2a, kappa
Clone Name: CPTC-ANXA1-1
Uniprot Id: P04083
Host Animal: Mouse
Clonality Id: Monoclonal
Reactivity Id: Human
Product Content: 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Alternative Name: ANXA1; ANX1; Annexin-1; Chromobindin-9; LPC1; p35
Application Note: Immunoprecipitation (2-4ug/mg protein); Western Blot (1-2ug/ml); ,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);
Categories Name 1: Antibodies
Categories Name 2: Cancer Marker
Storage Condition: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Immunogen Information: Recombinant full-length human Annexin A1 protein