BYK204165

DESCRIPTION

A selective inhibitor of PARP1 (IC50 = 44.67 nM for human recombinant PARP); selective for PARP1 over PARP2 (IC50 = 4,168 nM); inhibits hydrogen peroxide-activated PARP in A549 human lung epithelial, C4I human cervical, and H9c2 rat cardiac myoblast cells (IC50s = 229.09, 1,778.28, and 123.03 nM, respectively)

DETAILS

Inchi: InChI=1S/C15H12N2O2/c1-17-8-4-5-10(17)9-13-11-6-2-3-7-12(11)14(18)16-15(13)19/h2-9H,1H3,(H,16,18,19)/b13-9+
Purity: ≥98%
Raptas: Product Type|Biochemicals|Small Molecule Inhibitors|DNA Repair Enzymes||Research Area|Cancer|DNA Damage and Repair|PARP
Smiles: O=C1NC(C(C=CC=C2)=C2/C1=C\C3=CC=CN3C)=O
Inchikey: BTYSIDSTHDDAJW-UKTHLTGXSA-N
Cas Number: 1104546-89-5
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C15H12N2O2
Formula Weight: 252.3
Shelf Life Days: 1460