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10-043

Ruxolitinib . phosphate salt

ProSci

DESCRIPTION

Water-soluble phosphate salt of Ruxolitinib. Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19)

DETAILS

  • Cas: 1092939-17-7
  • Purity: greater than or equal to 98% (HPLC)
  • Smiles: N#CC[C@H](C1CCCC1)N(N=C2)C=C2C3=NC=NC4=C3C=CN4.OP(O)(O)=O
  • Formula: C17H18N6 . H3O4P
  • Storage: Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
  • Identity: Determined by 1H-NMR and MS.
  • Shipping: Room Temp
  • Inchi Key: JFMWPOCYMYGEDM-XFULWGLBSA-N
  • Solubility: Soluble in DMSO (10mg/ml).
  • Physical State: Lyophilized
  • Additional Names: INCB018424; INC 424
  • Predicted Molecular Weight: 306.4 . 98.0