mouse monoclonal IgG1; golgin 84 Antibody (D-5) is an IgG1 κ mouse monoclonal golgin 84 antibody (also designated golgin 84 antibody) that detects the golgin 84 protein of mouse, rat and human origin by WB, IP, IF and ELISA. golgin 84 Antibody (D-5) is available as both the non-conjugated anti-golgin 84 antibody form, as well as multiple conjugated forms of anti-golgin 84 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Golgin 84, also known as GOLGA5 (Golgi autoantigen, subfamily A, member 5), RFG5 (RET-fused gene 5 protein) or GOLIM5, is a ubiquitously expressed single-pass type II coiled-coil membrane protein. Localizing to the Golgi apparatus and predominantly found on membranes at the cis side of the Golgi stack, golgin 84 participates in the maintenance of Golgi structure and the formation of Golgi stacks and ribbons. The depletion of golgin 84 leads to fragmentation of the Golgi ribbon and reduced efficiency in protein transport. In addition, golgin 84 binds to active Rab 1 and associates with CASP (an isoform of CDP) in a golgin-tethering complex that is believed to play a role in intra-Golgi retrograde transport. During mitosis, golgin 84 is highly phosphorylated. Chromosomal translocations involving the gene encoding golgin 84 have been associated with cancer tissues. The chimeric proteins produced by this translocation are known as Ret-II and PTC5.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.