BIRB 796 (Doramapimod)

DESCRIPTION

BIRB 796 is a member of the N-pyrazole-N′-naphthly urea class of p38 MAPK inhibitors that binds to the kinase with slow association and dissociation rates without affecting JNK substrate phosphorylation. The p38 MAP kinase is involved in the production of pro-inflammatory cytokines such as TNF and IL-1. BIRB 796 is reported to be useful in the maintenance of cell lines by inducing self-renewal.

DETAILS

Purity: ≥98%
Synonyms: BIRB796
Cas Number: 285983-48-4
References: Pargellis, C., Tong, L., Churchill, L., Cirillo, P. F., Gilmore, T., Graham, A. G., ... & Regan, J. (2002). Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nature Structural & Molecular Biology, 9(4), 268-272. Regan, J., Pargellis, C. A., Cirillo, P. F., Gilmore, T., Hickey, E. R., Peet, G. W., ... & Moss, N. (2003). The kinetics of binding to p38MAP kinase by analogues of BIRB 796. Bioorganic & medicinal chemistry letters, 13(18), 3101-3104. Kumar, S., Boehm, J., & Lee, J. C. (2003). p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nature reviews Drug discovery, 2(9), 717-726.
Application: FA
Formulation: Crystalline solid
Chemical Name: 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
Molecular Weight: 527.7
Molecular Formula: C31H37N5O3
Storage Conditions: Product should be kept at -20°C.
Pubchem Openeye Can Smiles: CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5