Afobazole (hydrochloride)

DESCRIPTION

A multi-targeted anxiolytic drug with neuroprotective activities; binds to the sigma-1, melatonin MT1, and MT3 receptors, as well as MAO-A (Kis = 5.9, 160, 0.97, and 3.6 µM, respectively, in a radioligand binding assay); decreases the latency to enter, as well as increases the number of entries into and percentage of time spent in, the open arms of the elevated plus maze, indicating anxiolytic-like activity in passive stress-coping BALB/c, but not active stress-coping C57BL/6, mice at 5 mg/kg; decreases stroke volume and neuronal and oligodendroglial cell death in the brain in a rat model of ischemia induced by MCAO at 0.3 and 3 mg/kg

DETAILS

Inchi: InChI=1S/C15H21N3O2S.ClH/c1-2-20-12-3-4-13-14(11-12)17-15(16-13)21-10-7-18-5-8-19-9-6-18;/h3-4,11H,2,5-10H2,1H3,(H,16,17);1H
Purity: ≥98%
Raptas: Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Neuroprotection|Ischemia
Smiles: CCOC1=CC=C(N=C(SCCN2CCOCC2)N3)C3=C1.Cl
Inchikey: MYSRFAUFQZYTOV-UHFFFAOYSA-N
Cas Number: 173352-39-1
Formulation: A solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C15H21N3O2S • HCl
Formula Weight: 343.9
Shelf Life Days: 1460