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E0212Hu

Human Intercellular Adhesion Molecule 1, ICAM-1 ELISA Kit

Bioassay Technology Laboratory

DESCRIPTION

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.

DETAILS

  • GeneID: 3383
  • Species: Human
  • Storage: 2-8ºC
  • MASS(Da): 57,825
  • Synonyms: CD antigen CD54;ICAM 1;ICAM1;ICAM-1;Intercellular adhesion molecule 1;Major group rhinovirus receptor
  • Assay Time: 1h 30m
  • Assay Type: Sandwich
  • Gene Names: ICAM1
  • Reactivity: Human
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 9.56ng/L
  • Target Protein: ICAM1
  • Detection Range: 20-6000ng/L
  • Full Product Name: Intercellular Adhesion Molecule 1
  • Standard Solution: 6400ng/L
  • UniProt Accession: P05362