Aromatase (CYP19A1) Antibody (Center) Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 1588
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: CYP19A1
Other Names: Aromatase, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, Estrogen synthase, CYP19A1, ARO1, CYAR, CYP19
Availability: 2 weeks
Bio Background: CYP19A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation.
Bio References: Ikeda,S.,Am. J. Gastroenterol. 103 (6), 1476-1487 (2008)Dos Santos,(er) DNA Cell Biol. (2008) In pressNelson,Pharmacogenetics 14 (1), 1-18 (2004)
Primary Accession: P11511
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7293c was selected from the Center region of human CYP19A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.