BP7293c
Aromatase (CYP19A1) Antibody (Center) Blocking peptide
Abcepta
DETAILS
- Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
- Gene Id: 1588
- Category: Peptides; Blocking Peptides
- Subtitle: Synthetic peptide
- Gene Name: CYP19A1
- Other Names: Aromatase, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, Estrogen synthase, CYP19A1, ARO1, CYAR, CYP19
- Availability: 2 weeks
- Bio Background: CYP19A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation.
- Bio References: Ikeda,S.,Am. J. Gastroenterol. 103 (6), 1476-1487 (2008)Dos Santos,(er) DNA Cell Biol. (2008) In pressNelson,Pharmacogenetics 14 (1), 1-18 (2004)
- Primary Accession: P11511
- Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7293c was selected from the Center region of human CYP19A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.