T1185
Rofecoxib
TargetMol
DESCRIPTION
Rofecoxib (MK 966) binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecoxib is a synthetic, nonsteroidal derivative of phenyl-furanone with anti-inflammatory, antipyretic and analgesic properties and potential antineoplastic properties. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2.
DETAILS
- Cas: 162011-90-7
- Purity: 99.94%
- Smiles: O=C1C(=C(CO1)C2=CC=C(S(C)(=O)=O)C=C2)C3=CC=CC=C3
- Category: Compound
- Molecular Weight: 314.36
- Molecular Formula: C17H14O4S
Lead Time: < 1 week
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