4-Epianhydrochlortetracycline (hydrochloride)

DESCRIPTION

An inhibitor of MMP-9; a derivative of tetracycline; inhibits MMP-9 activity in a dose-dependent manner in an assay for collagen degradation; completely inhibits neutrophil-derived MMP-9 degradation of denatured collagen at a concentration of 500 μg/ml; lacks antibiotic activity

DETAILS

Inchi: InChI=1S/C22H21ClN2O7.ClH/c1-7-8-6-9-16(25(2)3)18(28)15(21(24)31)20(30)22(9,32)19(29)13(8)17(27)14-11(26)5-4-10(23)12(7)14;/h4-5,9,16,26-28,32H,6H2,1-3H3,(H2,24,31);1H/t9-,16+,22-;/m0./s1
Purity: >95%
Raptas: Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases
Smiles: O=C([C@@](C(C(C(N)=O)=C(O)[C@@H]1N(C)C)=O)(O)[C@@]1([H])C2)C3=C2C(C)=C4C(C(O)=CC=C4Cl)=C3O.Cl
Inchikey: WIOSVFADOBZUQR-PXAZKYFKSA-N
Cas Number: 158018-53-2
Formulation: A solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C22H21ClN2O7 • HCl
Formula Weight: 497.3
Shelf Life Days: 1460