10-4049-25 10-4049
Monoclonal antibody to CD161 (clone: ABM27F5)
Abeomics
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DESCRIPTION
CD161 is the human equivalent of mouse NK cell receptor P1A. It is a type II transmembrane glycoprotein with characteristics of the C-type lectin superfamily. The expression confines to lymphocytes found in human gut and liver, as well as blood, especially NK (natural killer) cells, Th17 (T helper 17) cells, and a population of unconventional T cells known as MAIT (mucosal-associated invariant T) cells. CD161 promotes T cell expansion and eventually has been identified as a marker of human IL-17-producing T cells. It plays a pivotal role in trans-endothelial migration and is also implicated in the pathogenesis of RA (rheumatoid arthritis) as well as graft-versus-host disease (GVHD).
DETAILS
- Gene: KLRB1
- App Id: FACS
- Antigen: CD161
- Gene Id: 3820
- Isotype: Mouse IgG2b, Kappa
- Format Id: Purified
- Clone Name: ABM27F5
- Uniprot Id: Q12918
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Purification: Protein G Chromatography
- Reactivity Id: Human
- Product Content: 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
- Alternative Name: Killer cell lectin-like receptor subfamily B member 1, C-type lectin domain family 5 member B, HNKR-P1a, NKR-P1A, Natural killer cell surface protein P1A, CD161
- Application Note: FACS analysis: 0.5-1 µg/10^6 cells
- Storage Condition: Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
- Immunogen Information: Full length recombinant protein of hCD161 was used as the immunogen for this antibody.
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