mouse monoclonal IgG1; AOX1 Antibody (D-8) is an IgG1 κ mouse monoclonal AOX1 antibody (also designated AOX1 antibody) that detects the AOX1 protein of human origin by WB, IP, IF, IHC(P) and ELISA. AOX1 Antibody (D-8) is available as both the non-conjugated anti-AOX1 antibody form, as well as multiple conjugated forms of anti-AOX1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The formation of free radicals is an adverse consequence of metabolism. Free radicals endanger cells by causing oxidative damage to membranes and can lead to interruption of DNA sequences, thereby potentially resulting in carcinogenesis. As a member of the molybdo-flavoenzymes family of proteins, AOX1 (Aldehyde oxidase 1) is a 1338 amino acid cytoplasmic protein that catalyzes the oxidation of a variety of aldehydes, leading to the production of hydrogen peroxide. Under certain conditions, AOX1 can catalyze the formation of the superoxide free radical. Defects in oxygen radical metabolism have been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS), an autosomal dominant neurodegenerative disorder characterized by the death of motor neurons in the spinal cord, brain and brainstem. Significantly, AOX1 is highly expressed in the ventral horn of the spinal cord and the gene that encodes AOX1 is located in a chromosomal region that is frequently found to be implicated in ALS2. This evidence suggests that AOX1 is a candidate gene for ALS2.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.