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E6266Hu

Human Thiopurine S-methyltransferase, TPMT ELISA Kit

Bioassay Technology Laboratory

DESCRIPTION

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:657528, PubMed:18484748). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.

DETAILS

  • GeneID: 7172
  • Species: Human
  • Storage: 2-8ºC
  • MASS(Da): 28,180
  • Synonyms: Thiopurine methyltransferase;Thiopurine S-methyltransferase;TPMT;TPMTD
  • Assay Time: 1h 30m
  • Assay Type: Sandwich
  • Gene Names: TPMT
  • Reactivity: Human
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 0.29mU/mL
  • Target Protein: TPMT
  • Detection Range: 0.5-200mU/mL
  • Full Product Name: Thiopurine S-methyltransferase
  • Standard Solution: 240mU/mL
  • UniProt Accession: P51580