RP01450
Recombinant Human gp140/CDCP1/CD318 Protein
ABclonal
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DESCRIPTION
CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and both, typical and atypical (cancerous) colons. It interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. It also interacts with SRC and PRKCG/protein kinase C gamma. CDCP1 is taken as a key regulator of EGF/EGFR-induced cell migration. It has been shown that signaling via EGF/EGFR induces migration of ovarian cancer Caov3 and OVCA420 cells with concomitant up-regulation of CDCP1 mRNA and protein. Consistent with a role in cell migration CDCP1 relocates from cell-cell junctions to punctate structures on filopodia after activation of EGFR. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and immature hematopoietic stem cell subsets.
DETAILS
- Tag: C-His
- Source: HEK293 cells
- Gene Id: 64866
- Species: Human
- Lead Time: 3-5 weekdays
- Swiss Prot: Q9H5V8-1
- Research Areas: Other Recombinant Protein
- Alternative Names: CD318, TRASK, SIMA135,CDCP1,SIMA135,TRASK
Equivalent Items
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