30-1834
Anti-CD8 Monoclonal Antibody (Clone:MEM-31)-Biotin Conjugated
Abeomics
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DESCRIPTION
The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha-beta but not alpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
DETAILS
- Gene: CD8A
- App Id: FACS, IP
- Antigen: CD8
- Gene Id: 925
- Isotype: Mouse IgG2a
- Clone Name: MEM-31
- Uniprot Id: P01732
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Conjugate Id: Biotin
- Reactivity Id: Human
- Alternative Name: T-lymphocyte differentiation antigen T8/Leu-2, CD8a, MAL
- Storage Condition: Store at 2-8°C. Do not freeze.
- Immunogen Information: Crude thymus membrane fraction.