36680
rac-Benpyrine
Cayman Chemical
DESCRIPTION
An inhibitor of the TNF-α-TNFR1 protein-protein interaction (IC50 = 0.109 µM); reduces TNF-α induced cytotoxicity in L-929 fibroblasts at 10 µM; prevents nuclear translocation of NF-κB in RAW 264.7 macrophages; improves survival in a mouse model of LPS-induced endotoxemia and decreases disease severity in mouse models of collagen-induced arthritis and imiquimod-induced psoriasis at 25 mg/kg
DETAILS
- Inchi: InChI=1S/C16H16N6O/c23-13-6-12(8-22(13)7-11-4-2-1-3-5-11)21-16-14-15(18-9-17-14)19-10-20-16/h1-5,9-10,12H,6-8H2,(H2,17,18,19,20,21)
- Purity: ≥98%
- Raptas: Product Type|Biochemicals||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock
- Smiles: O=C1N(CC2=CC=CC=C2)CC(NC3=NC=NC4=C3NC=N4)C1
- Inchikey: HUWOMAVUXTXEKT-UHFFFAOYSA-N
- Cas Number: 1333714-43-4
- Formulation: A solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C16H16N6O
- Formula Weight: 308.3
- Shelf Life Days: 1460